Penegra 100 mg is a dosage of Sildenafil that helps to cure impotence in men called ED (Erectile Dysfunction). It belongs to the PDE-5 inhibitors group and is available on MedzPalace. Read more about its review and dosage.
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What is Penegra 100 Mg?
Penegra 100 mg is a very popular and fast-acting medicine that is prescribed by doctors to patients who are seeking treatment for a medical condition called erectile dysfunction. In this condition, the penis does not become sufficiently hard and men are unable to attain and maintain an erect penis with the rigidity needed for sexual intercourse. It occurs in middle-aged men and it also commonly occurs after the age of 65 years. Any sort of vascular, neurogenic, hormonal, pharmacological, or psychogenic causes may be the cause of such a disorder.
Is Penegra 100 Mg Safe?
Yes, it is safe. It has been properly tried and tested and patients can avail of it after getting a prescription from a doctor.
Manufacture
Zydus Cadila or Cadila Healthcare Limited is the pharmaceutical company that manufactures Penegra 100 mg. This company mainly manufactures generic drugs and it is a fully integrated company that caters to the Pharmaceutical needs of patients around the globe.
Composition
Sildenafil citrate is the active drug contained in Penegra 100 mg. It is the first-ever effective drug for the treatment of erectile dysfunction in men and it is taken orally.
Storage
Store it at room temperature, away from direct heat, sunlight, and humidity, in a closed container, preferably at a temperature below 30 degrees Celsius. It can be harmful if it is ingested by your pets and it is not for the use of children so keep it away from them.
What are the Uses of Penegra 100 Mg?
Medical Uses
Sildenafil is an oral drug, it is very potent and it selectively inhibits cGMP-specific phosphodiesterase type 5. Its significance will be discussed later on in the article. It is also used to provide relief from motion sicknesses and hypotension.
Non-Medical Uses
Although it is not recommended some men use Penegra 100 mg as an aphrodisiac to improve their sexual performance and sexual experience.
How to Take Penegra 100 Mg Pills?
Consume the tablet along with plenty of water without crushing, chewing, or breaking it. You have to gulp it down directly with the water.
How Does Penegra 100 Mg Work?
Penile erection occurs when there is increased blood flow to the penis which happens if there is smooth muscle relaxation in the corpus cavernosum sinusoids. Nitric oxide is released in men when they are sexually stimulated and this increases guanylate cyclase activation which finally causes the synthesis of cyclic guanosine monophosphate. This cGMP causes smooth muscle relaxation which results in an increase in arterial flow and corporal veno-occlusion. In the cells, cGMP is destroyed by phosphodiesterase enzymes. Four types of phosphodiesterase isoforms are detected in human penile tissue however, the predominant isoform in this tissue is type 5. Sildenafil increases the cGMP concentration in corporeal smooth muscles by inhibiting its degradation as it inhibits PDE 5 as it is 10-10,000 times more selective on PDE 5 than other phosphodiesterase isoforms are. It also strengthens the relaxant effect of nitric oxide.
Side Effects of Penegra 100 Mg
Common Side Effects
Weakness
Confusion
Indigestion
Palpitations
Nausea
Rare Side Effects
Ecchymosis
Mental depression
Photophobia
Fever
Seizures
Penegra 100 Mg Dosages
Take it an hour before you will have sex but do not take it more than once in 24 hours.
Missed Dose
In case you have missed a dose of Penegra 100 mg, take the dose as soon as you remember it but do not overuse it as compensation.
Overdose of Penegra 100 Mg
Symptoms like flushing, headache, back pain, etc. can occur if you have taken the dose more than the recommendation.
Interactions
Alpha-Blockers
It can cause symptomatic hypotension in patients by affecting arteries. It dilates them and affects the baroreflex response.
Amlodipine
It will also cause vasodilation but it is a calcium channel blocker and has different mechanisms of action.
Ritonavir and Other CYP3A4 Inhibitors
They inhibit the human cytochrome responsible for the metabolism of Sildenafil. So they can increase the blood levels of drug toxicity of Sildenafil.
Alcohol
It can potentiate the vasodilating action of Sildenafil if taken in large quantities. It is better to avoid it altogether.
Contraindication
Nitrates
It can be very dangerous as it seriously reduces blood pressure and can cause myocardial infarction. Avoid it for about 24 hours after taking Sildenafil.
Hypersensitivity Reactions
Discontinue the use of Penegra 100 mg if you are allergic to it and find an alternative, there are plenty. The common allergic reactions are myalgia, dizziness, rashes, etc.
Warnings and Precautions
Cardiovascular
It is used for the treatment of pulmonary arterial hypertension as it reduces blood pressure. Similarly, it can be harmful to patients with hypotension.
Prolonged erection and Priapism
It is caused due to overdosing the drug and this condition needs immediate medical treatment as it can cause permanent damage to the penis.
Effects on the eye
Along with its effect on the enzyme PDE, sildenafil also has a somewhat inhibiting effect on the isoenzyme PDA six. This isozyme is involved in the photoreceptor transduction in the retina in the eye. Due to this weak inhibition, a slight deterioration of color vision occurs in the patients. Mainly the blue-green color discrimination occurs in the recipients. Some reports of a sudden loss of vision due to nonarthritic ischemic optic neuropathy have been there among users of PDE five inhibitors. Sildenafil can also cause bleeding in the eyes.
Hearing loss
Many cases have been reported by the patients who are taking Sildenafil in which they have stated that they were experiencing partial or complete hearing loss. This can be attributed to the fact that PDE-5 inhibitors may induce sensorineural hearing loss by some physiological mechanisms which cause damage to the middle ear and the inner ear of the patients.
How Does it React with Other PDE5 Inhibitors?
Sildenafil is a PDE 5 inhibitor and so are the other drugs that are used in the treatment of erectile dysfunction in men. Now all these drugs have a similar mechanism of action. If they are being used in combination with Sildenafil, it is recommended that you only do it after getting it approved by your doctor because if their dosage is not regulated appropriately then they can cause adverse side effects which are similar to the ones which are related to Sildenafil overdosing.
Effect on bleeding
Therefore the use of this drug in high doses may increase the chances of intracranial bleeding in patients during sexual intercourse as it will cause cerebral vasodilation. However, the relationship between the dose of Sildenafil and the chances of developing intracranial bleeding has not been clearly demonstrated yet.
Counseling patients about sexually transmitted diseases
As we now know the mechanism of action of Sildenafil, it is clearly evident that it will not protect the patients from catching sexually transmitted diseases. The patient needs to take adequate precautions to avoid that. It will also not prevent pregnancy so it is important to indulge in safe sex.
Why buy Penegra 100 Mg from Medzpalace.com?
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Penegra 100 Mg reviews
We have already discussed all the modes and methods in which Penegra 100 mg works. It is also a very popular and widely appreciated drug. So the patients who are in need of this medicine should definitely go for it without any worry. A lot of studies have been conducted on a lot of cases that have confirmed its safety and efficacy.Poxet 30 mg
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